Antibacterial substances are abundant in medicinal herbs, which are used in many extremely effective traditional medical therapies. Conocarpus lancifolius Engl. (C. lancifolius), a species of the Combretaceae family of plants, therefore has a wide range of therapeutic uses for the handling of haemophilia, inflammation, illness, eye ailments, fever, diabetes and headache. haemorrhaging in addition to its application to treat conditions affecting the reproductive, urinary, and sexual systems. The study's goal was to assess the antibacterial efficacy, In vitro antioxidant, anti-inflammatory of several solvent-based the extraction of C. lancifolius leaf material. The investigation started in March 2023 when C. lancifolius leaves were collected from the trees at the Vellalar College of Pharmacy in Erode, India. To make the extracts, the maceration technique was employed. Flavonoids, alkaloids, saponins, tannins, and anthraquinones were all detected in the phytochemical test results. Using the use of the agar thoroughly diffusion method, the antibacterial capacity of C. lancifolius extracted from leaves was evaluated. At the concentration of 100 g/mL level of probability, Gram-positive bacteria including Staphylococcus aureus in addition to Bacillus cereus, respectively (18 and 21 mm) and gram-negative microorganisms Escherichia coli combined with Klebsiella pneumonia (23 and 20 mm) are considerably inhibited. Additionally, it has the strongest antifungal activity (20 mm) against Candida albicans. While the ethanol extract of the leaves significantly inhibited both Gram-negative bacteria like Escherichia coli as well as the pneumonia-causing bacteria Klebsiella pneumonia (22 and 19 mm) and Gram-positive bacteria like Staphylococcus aureus and the yeast Bacillus cereus (18 and 20 mm). When compared to normal ascorbic acid, which had an antioxidant activity of 87.96%, C. lncifolius extract with chloroform exhibited a substantial antioxidant activity of 62.96% inhibition. When compared to a larger dose of normal diclofenac (84.11%), the more potent quantity of C. lncifolius extract with chloroform significantly inhibited inflammation by 75.12% under similar circumstances. Because there are biologically active compounds in the herbal preparation, the current investigation found that C. lancifolius may be a good therapeutic candidate